Rivals Buster and Plucky decide to throw an epic pizza party and are shocked to find out they're actually getting along while Babs and Sweetie get into their first roommate disagreement.
Babs realizes Acme Loo's school paper has closed so she starts a new one with her pal Sweetie. But when Plucky starts a gossipy tabloid to compete against them, which paper will come out on top?
Buster and Sweetie join the Tooney Ball team during Electives Week while Babs and Plucky tackle the basics in Anvils 101, leaving Hamton on a journey to fix his indecisiveness.
Hamton gets into medical school but soon realizes it's not at all what he imagined. Buster desperately tries to find a way to bring his pal back to Acme Loo.
Buster finds a cloning machine at Wile E. Coyote's yard sale that he uses to make another Buster, Babs and Sweetie snag a time machine that they use to open a vintage clothing store.
Babs is excited to be the first student director of the annual toon showcase, but she quickly learns it won't be easy as she thought. Meanwhile, with the help of his friends, Hamton learns to shine in the spotlight.
Plucky goes home with Babs and Buster for Spring Break and quickly becomes the new star of Burrowville, while Hamton and Sweetie embark on the adventure after accidentally missing their train stop.
It's picture day at Acme Loo! Babs accidentally shrinks herself, Buster fails to get the perfect photo day haircut, Plucky gives lessons on being direct, and Hamton struggles to find his photo persona.
The toons take Marvin the Martian's class, and head to space. Buster tries to cheer up a homesick Babs, Plucky searches for a space outfit, and Sweetie is too obsessed with a video game to notice any of it - even when the aliens attack!
Babs and Buster attend a twin convention but are soon ostracized for not being exactly the same. Hamton accidentally becomes famous, and Plucky steps up as his manager. And Sweetie won't let anything stop her from finishing her board game.