A small Ohio town is shaken in 2010 when Tina Herrmann, 31, Stephanie Sprang, 41, Sarah Maynard, 13, and Kody Maynard, 11, mysteriously vanish. Investigators find the family's home covered in blood but very few clues. A tiny detail helps authorities track down a suspect, but they need answers from him before time runs out.

Authorities investigate when an art teacher is killed in her own home, and they bring her husband and a growing list of suspects into the interrogation room to face hard-hitting questions in the hopes of learning why the teacher was murdered.

Detectives rush to find a missing girl who was staying with a murder victim, and as they investigate the dramatic situation, a familiar name becomes a prime suspect, so they interrogate him in the hopes of finding the girl alive.

After a woman is brutally murdered just a week before her wedding, detectives interrogate three possible suspects, including her fiance.

A woman goes missing and interrogators have tough questions for the friend she was last seen with.

A woman is murdered by the foster daughter she took in. But an open-and-shut case becomes more complicated as evidence emerges that the foster daughter may not have acted alone.

After a woman goes missing, a married Navy police officer contends with tough questions about his romantic relationship with the victim; after a decade on the run, officers interrogate the wife accused of murdering her husband.

Detectives put pressure on their prime suspect as they investigate the shooting death of a U.S. postal employee to determine if the killing was intentional or if the postal worker's death was actually an accident, as the suspect claims.

Investigators wonder if a nurse's aide may be a serial killer after several mysterious deaths occur at a VA hospital located in West Virginia.

A man becomes the prime suspect in a murder investigation after finding his partner brutally murdered.

A young woman's body parts are found in a suspect's plumbing and freezer and when he's brought into the interrogation room, his bizarre behaviour stuns even the most seasoned detectives.

After a 20-year-old man is crushed by a truck that fell off its jack, the victim’s father is brought in to face questions over whether it was really an accident…or murder.

A man is gunned down outside a local shop and authorities interrogate two of his acquaintances to find out which one of them pulled the trigger. Plus, the shocking interrogation of a woman accused of mowing down two children with her car.

A man’s body is found in a wooded area and the victim’s neighbor is brought into the interrogation room, where evidence mounts even as he’s being interviewed.

After a young father is brutally beaten and left to die on the side of a road, four acquaintances are interrogated separately and the finger-pointing begins.

A young man accused of killing a beloved 52-year-old woman changes his tune after a cigarette break and DNA technology helps detectives solve a decades-old murder mystery.

After three members of a Minnesota family are shot by an intruder, leaving only one survivor, a neighbor is brought into the interrogation room for some tough questions.

Authorities question a woman who traveled with serial killer about whether she was a victim or an accomplice. Plus, a bone-chilling confession from a man who freely admits to killing a college student.

A prolific serial killer’s confession in the murder of a young woman turns out to be a hoax but decades later a more likely suspect is ready to talk, under one condition.

The search for a missing priest leads detectives on a multi-state manhunt for a suspect who may be the only person with the answers to his whereabouts.

When a 25-year-old college student vanishes on Christmas Eve, investigators must piece together the details of a first date gone tragically wrong.

When a 70-year-old grandmother passes away suspiciously on a road trip, investigators uncover a sinister murder plot while searching for her remains.

Investigators search for the mystery killer after a man and woman are found shot on the side of the highway, and they find a break in the case when a deputy comes across the victim's missing car filled with guns and silencers.

After the dismembered remains of a missing woman are found in a freezer, investigators uncover a love triangle and a murderous conspiracy to conceal the truth.

A series of random nighttime shootings has the city of Phoenix on edge as police try to end the reign of terror and interrogate two suspects.

After 22 years, a local news story reignites a decades-old cold case, leading investigators to question a close-knit circle of friends who they believe are hiding the truth about the disappearance of a 25-year-old man. Can investigators convince the group of friends to reveal who the killer is and finally get justice for the victim?

After a successful businessman is brutally strangled, investigators become suspicious of his widow and her secret friend.

After decades on the run, a serial killer faces tough questions in the interrogation room and after a woman is found dead in the middle of the road, the finger pointing begins when three suspects are interviewed.

In 2012, 26-year-old Timothy Rambo Ramsey is killed in a drive-by shooting, but the investigation yields little evidence, and the case goes cold for six years; when detectives re-examine the evidence, they uncover a violent feud between two men.

Investigators respond to a local hospital where an elderly woman fights for her life after a brutal assault; the victim is able to describe the vicious assault; quick detective work points the officers to a suspect, but he stonewalls detectives.

When an otherwise healthy young woman is admitted to the hospital with sudden organ failure, an anonymous tip leads authorities to investigate a pattern of unexplained deaths in her family and a shocking prime suspect.

When an 85-year-old man passes away after years of failing health, authorities quickly rule it a natural death and close the case; years later, a bombshell recording reveals that those closest to him may have played a hand in his passing.

Ten years after a young mother allegedly abandoned her family, her mother-in-law reveals a shocking secret: she believes both of her daughter-in-law's lovers murdered her.

Investigators question the mother of a deceased baby and her estranged husband to determine how the child died and ended up in a cardboard box, and as they search for answers, they determine who is responsible for the awful crime.

At the scene of a chilling triple murder in Northern Maine, detectives recover DNA evidence that suggests an out-of-town visitor may be behind the brutal crime.

In a story that gripped the nation, three Cleveland women are rescued ten years after vanishing from the city's streets; authorities must confront the man at heart of this notorious crime to unravel the sinister details surrounding the abductions.

After police respond to an apparent suicide, the case takes an unexpected turn when investigators cannot find a gun near the body.

After an 80-year-old woman vanishes, local police and the FBI team u in the pursuit of a suspected serial killer.

When a young woman vanishes, detectives zero in on her controlling estranged husband - whose story continually changes in the interrogation room.

A mother from Florida vanishes into the night after celebrating her daughter's first birthday; in their search to find her, the police seek answers from the father of her child.

When police pull over a local man for violating his parole, the case takes a shocking turn when he suddenly confesses to multiple brutal murders.

A woman calls 911 with a story of being abducted and forced into the trunk of her car by a masked assailant, who fatally shoots her girlfriend; investigators attempt to determine if the murder was the result of an elaborate kidnapping plan.

Following the discovery of a woman's body in a neighborhood dumpster, investigators narrow down their suspect list to three people; the list includes two brothers.

A brutal home invasion results in a man being beaten to death and set on fire. As investigators race to find the perpetrator, a shocking 911 call pits two brothers against each other in the interrogation room.

A small Kentucky community is rocked to its core when a prominent family is gunned down in their home after Sunday church service. The sole survivor of the attack, the victims’ son, claims he killed an intruder in self-defense. But the detectives’ investigation takes a shocking turn when someone comes forward with evidence that the son may not be as innocent as he claims. Can interrogators uncover the truth of who’s really behind the family farm massacre?