Giulio Cesaroni and Lucia Cudicini, he a widower, she separated, meet again after twenty years in Rome. They realize they still love each other and decide to get married, so Lucia's daughters, Eva and Alice, arrive from Milan and move in with the Cesaronis. Getting to know Marco, Rudi and Mimmo, Giulio's sons, is not easy and things are also complicated by uncle Cesare, Giulio's brother, and his jealousy.

Sergio wants Lucia to get back together with him, but after her ex refuses, the ruthless manager goes to Giulio's liquor store and threatens to take away his future wife, daughters and job. Giulio acts on impulse and doesn't hesitate to punch him, so Sergio, with the complicity of a doctor friend, makes the Cesaronis believe he is dying.

Lucia discovers Sergio's deception and Giulio, having escaped danger, immerses himself once again in the preparations: he wants his wedding party to be unforgettable for the entire neighborhood. Unfortunately, finances are languishing and Giulio finds himself entangled with a financial company and forced to lie to Lucia. The latter, having discovered her future husband's lies, decides to punish him to teach him a lesson.

Giulio, in an excess of romanticism, leads Lucia to the place where twenty years before he had made love to her for the first time, but unfortunately he gets the wrong place. Lucia, with a deadly pressure, manages to make Giulio confess: the other, the accused girl, was Stefania, now Ezio's wife. Lucia punishes her friend by wrecking her car.

After a meeting with the school psychologist, Giulio tries to imitate Lucia in his relationship with his children, who are worried about their father's change. Meanwhile, Lucia feels lost when Eva confides in her that she intends to make love for the first time with her boyfriend and has a tough fight with her daughter.

There is tension in the Cesaroni household. Lucia is so busy with work and household chores that Giulio hasn't been able to have a moment of intimacy with her for several days. Meanwhile, Marco has a fight with Lucia, guilty of having taken the guitar from the closet that reminds the boy of his deceased mother. However, things smooth out and Marco starts playing again.

Marco and Giulio have a tough fight over the young man's decision to become a musician. Meanwhile, Lucia receives a beautiful necklace as a gift from an anonymous admirer. The woman thinks that the gift was given to Giulio and when she discovers that the necklace actually came from her admirer Andrea, she flies into a rage.

Don Gervasio, the president of the Romulana, the neighborhood soccer team, dies suddenly, so Cesare and Andrea run for the succession. The innkeeper, thanks to Ezio's help, becomes the new president but, for the good of the team, gives up his place to the wealthier rival. The latter, after another attempt to seduce Lucia, receives Giulio's violent congratulations.

Rudi takes part in a psychological test and the result, to everyone's surprise, is that the boy is a genius. Giulio, enthusiastic, does everything to satisfy his son's needs and stimulate his intelligence. Alice, suspicious, discovers that the Leonardo da Vinci of Garbatella copied the answers. Lucia convinces Rudi to confess and the father's punishment is not long in coming.

Marco seems increasingly strange and it is now clear to everyone that he is in love. However, no one suspects that the lucky girl is Eva. Meanwhile, Sergio shows up at the Cesaroni house and, on the verge of being named Cavaliere del Lavoro by the President of the Republic, he would like to take advantage of the opportunity to embarrass Giulio and win Lucia back.

Giulio must serve a two-match suspension as the Romulan coach following a heated argument with a referee and is forced to ask Ezio to replace him on the field. Meanwhile, little Mimmo is struggling with a difficult assignment for him: an essay about his mother. The child, who remembers nothing about Marta, his dead mother, asks his father and brothers for news.

Marco learns that Eva is going to London for a weekend and would like to accompany her, so he tries to scrape together the necessary money and his uncle Cesare finds him a job as a liscio player with a small orchestra of over-sixty year olds in a club. Meanwhile, Ezio, because of a prank by Giulio and his brother, argues with Stefania and leaves home.

Ezio and Stefania argue furiously and involve Giulio and Lucia in their delusions. Meanwhile Marco wins a music competition but is sad because he would like to confess his love to Eva and to complicate matters there is also Cristian, the girl's ex who resurfaces after a long time, and Giulio, who, not understanding the young man's feelings, urges him to forget his stepsister.

After years of absence, Augusto Cesaroni, Giulio and Cesare's brother, leaves the United States and returns to Rome. Giulio, who has always believed Augusto to be a rich and powerful former race car driver, has to change his mind. The man, full of debts, has actually shown up only to claim his share of the liquor store. Meanwhile, Rudi blackmails Alice because of his stepsister's affair with a boy.

While Augusto, out of the hospital, starts a relationship with Gabriella, Eva returns from Milan with her friend Beatrice. Giulio, hoping that Marco will fall in love with her and forget his stepsister, convinces his son to organize a party. Marco, however, disappoints his father's expectations. Meanwhile, Lucia, due to the return of Professor Zuppante, has to leave school.

Giulio, Cesare and Ezio are about to leave for the traditional fishing trip when Sergio, seriously ill, shows up again. The three, suspicious of the sudden arrival of Lucia's ex, kidnap him and take him with them to Abruzzo. Upon returning to Rome, his illness revealed, the man says goodbye to his family and leaves for treatment in the United States, accompanied by Lucia, encouraged by Giulio.

Gabriella, upset by Augusto's abandonment, shows up at the Cesaroni house accompanied by a fortune teller, who instills in Ezio the doubt that Walter is not really his son. After undergoing a medical test, which shows he is sterile, the mechanic is convinced that the father of his son is Giulio. Luckily, Stefania manages to clarify the matter.

Alice hangs out with a bully named Riccardo who, in order to be accepted by Giulio, tries to appear serious and studious. When the innkeeper, with Rudi's help, discovers the boy's true nature, he reserves his most classic punishment for him: the broom. Meanwhile, Marco, while still being troubled by his feelings for Eva, lets himself be seduced by Rachele, the new teacher.

Rudi is growing up and seems to be morbidly attracted to girls. So Giulio, not without embarrassment, begins to address the topic of sex with his children. Rudi, however, wants to move from theory to practice and invites his friends home to play the "postman game". When the innkeeper catches Rudi kissing Alice, he goes back to his old ways. Meanwhile, Eva becomes jealous once she discovers the relationship.

After a strange phone call, Giulio becomes convinced that Lucia is being pursued by a man. After entrusting his children to the care of Ezio and Stefania, the innkeeper leaves for the United States with Cesare and Gabriella, but during the flight the Cesaroni brothers are mistaken for two attackers and repatriated. Upon his return to Italy, Giulio discovers that the mysterious John is none other than Lucia's gay roommate.

Giulio needs to spend more time with his children and, in agreement with Cesare, hires a maid, Daniela. The woman, however, falls in love with him and the innkeeper must try in every way to resist the young woman's assaults. Meanwhile, Alice, to impress a boy, joins the school soccer team coached by Cesare and Lucia returns from America.

Little Mimmo is in love with his classmate Sara, who plays the princess in the school play. The child, in order to be close to her, accepts the part of the maid of honor and asks Lucia for help in getting ready. Giulio, noticing the preparations for the play, misunderstands Mimmo's interest in the female universe and, believing him to be gay, tries to involve him and convert him to male activities.

Giulio helps Rudi study for his class test, but the boy gets a bad grade for the umpteenth time. Meanwhile, the school newspaper edited by Alice reports a secret relationship between a student and a teacher, and Rachele, thinking that Marco is to blame, tries to get revenge. Rudi and Alice manage to make amends.

At school Rudi and Alice compete for the role of gang leader, while Lucia, depressed by her absence from teaching, devotes herself with obsessive attention to household chores, worrying Giulio. Marco, abandoned by Rachele, confesses to Eva that months before he had been in love with her.

While Eva tries to win over Marco, who is distressed by the end of his relationship with Rachele, Giulio and Cesare find themselves in trouble with the tax authorities. With financial help from Gabriella, the two must accept the woman, Lucia and Stefania as assistants in the management of the wine shop. The business starts up again with flying colors, but the men are not happy with the female presence.

Lucia plans a group vacation at a campsite in Sardinia, but friends and relatives have other plans and one by one they back out, so Giulio and Lucia are forced to leave alone. Eva, convinced by Giulio to forget Marco, for the good of the family, follows Veronica to Croatia, while Marco and Walter leave for Greece.

The end of the holidays seems to bring some news to the Cesaroni household: Lucia, suffering from strange ailments, fears she is pregnant and tries to talk to Giulio who, misunderstanding, believes that Stefania is expecting a child. Marco, meanwhile, has resumed his relationship with Rachele.

Cesare confesses to Giulio and Ezio the reason for his breakup with Pamela: he is a virgin and did not have the courage to reveal it to his fiancée. The two, to help Cesare, send him to a prostitute, but Pamela surprises him and misunderstands the situation.

The innkeeper Giulio Cesaroni and his family are dealing with the terrible new neighbors, who moved from Padua: the Barilons. Meanwhile Marco, who has broken up with Rachele, tries to get closer to Eva. The girl, however, is not at all well disposed.

Giulio is worried because his wife Lucia is not getting pregnant. After having tried the unlikely treatments proposed by Cesare and Ezio without obtaining results, the innkeeper asks his friend Ezio to be a donor for artificial insemination.

Lucia, taken by the sacred fire of art, enrolls in a theater course together with Stefania but Giulio, influenced by Ezio's worries, becomes jealous. The career of the new actress, however, does not last long.

Cesare accidentally hits Barilon's dog with his van. Giulio and Ezio are convinced that the innkeeper killed a tax inspector and plan to report him to the police. Alice babysits her friend Umberto's brother.

Ezio seems to have lost the sexual connection with his wife, so much so that he falls asleep during their intimate moments. Lucia, against Giulio's wishes, gives her friend a hand so that he can be forgiven by his wife, but Ezio misunderstands.

There will soon be a dance competition. Giulio and Lucia, unbeknownst to each other, take tango lessons but, while Lucia, thanks also to the skill of her partner Barilon, makes great progress, her husband is clearly in difficulty.

Giulio and Lucia leave to spend a weekend of absolute relaxation in the countryside. Unfortunately for them, however, their vacation is disturbed by the presence of the Barilons, guests of the same agriturismo. In Rome, meanwhile, Stefania does everything she can to adopt a child, while Marco and Eva organize a party together with Walter without their parents' knowledge.

Giulio, to impress his friends Ezio and Cesare, makes up a story: he says he kissed the model Alena Seredova. Together with Lucia, Giulio surprises Marco and Eva in bed together. The story causes him to have a heart attack.

Giulio is in the hospital, cared for by the loving Lucia. Ezio and Cesare do everything they can for their friend, getting into all sorts of trouble, while the little Cesaronis blame themselves, believing they are responsible for what happened. The crisis is overcome and the innkeeper can return to the affection of his loved ones. Marco and Eva apologize to their father for what happened, but this time, being forgiven will not be easy.

There is tension in the Cesaroni household over Marco and Eva's affair. While they are waiting for Giulio to return from the hospital, the two young people are wondering about the future of their relationship: Eva is considering dropping out of school.

Giulio discovers that years before his father, to indulge his passion for engines, had left him a mechanical workshop, which was then sold, without his knowledge, by Cesare to pay off the debts of the liquor store.

The Cesaroni family and the customers of the wine shop are in a frenzy: soon there will be a derby between the football team of the Garbatella neighborhood and the team of the neighboring neighborhood. Captain Giulio, overcoming Lucia's resistance, decides to participate.

Giulio and Ezio are convinced that Cesare is abusing drugs, while the poor innkeeper is struggling with a furious stomach ache, due to the consumption of expired sardines. Lucia, who returns to teach in Rudi's class, attracts the antipathy of her parents.

Cesare sees Pamela again, the two still love each other and start dating again. The innkeeper, however, cannot confess to her that he is a virgin and instead of sincerity, he prefers to disguise himself, on Giulio's advice, behind the false identity of the wealthy Achille.

Giulio and Cesare are convinced by Ezio to join him, to sell sandwiches and wine with a traveling stall. The company works, but soon Ezio, instigated by Barilon, demands most of the profits, starting a war between the partners.

Due to an accident in the wine shop, Giulio is forced to welcome the amnesiac Francesco into his home, who soon wins the sympathy of the entire family. Meanwhile, Cesare and Ezio discover his true identity: Francesco's name is Oreste and he is gay.

On the advice of the doctor, who fears a new trauma, the Cesaronis indulge the amnesiac Francesco who believes himself to be Giulio. The man usurps the innkeeper's place at home, in the wine shop and also next to Lucia.

Cesare, to encourage little Mimmo to take swimming lessons, boasts of being a great swimmer, but in the pool he is forced to confess that he fears water more than his nephew, keeping away from it. Faced with Mimmo's difficulty during the race, Cesare, however, does not hesitate to dive in to accompany the child to the finish line. Lucia and Giulio, meanwhile, try to stay close to Eva and Marco, still suffering from the end of their relationship. While Marco prefers to stay alone, Eva, resumes her relationship with Alex.

Little secrets torment the Cesaronis. Lucia throws a water bomb that hits Stefania and makes her miss the meeting of her life with a famous writer, while Giulio and Ezio believe that Cesare hides his gambling addiction from them.

Cesare, having escaped a collision with a chandelier that fell into a liquor store just as the procession of San Saverio was passing through the neighborhood, believes he has been miraculously saved and undergoes a sudden conversion, worrying Giulio.

The Cesaroni's great soccer dream is about to come true: Romulana could make the jump in category. Giulio uses legal and illegal means to achieve victory, while Cesare does everything he can to ensure Romulana loses.

Giulio and Cesare are convinced that Ezio has contracted the Ebola virus, infected by the parish priest Don Luciano who has just returned from Africa. The three friends believe they are infected and lock themselves in a wine shop, drunk, awaiting death.

Rudi, miraculously promoted, refuses to work in the wine shop, resorting to the blue telephone. The intervention of social services helps Giulio and Lucia to teach the little rascal a lesson. Meanwhile, Eva's departure does not go down well with Lucia.

Giulio and Lucia Cesaroni organize the ritual barbecue that marks the end of summer. Among those present are Giulio's inevitable brother, the mechanic Ezio Masetti and his wife Stefania, a friend of Lucia and the principal of the school where they both teach. Obviously Lucia's mother, Gabriella, is also there, while the youngest of the family, Mimmo, observes that this year the doors of middle school are opening for him. For Alice and Rudi, always dog and cat, instead the much more terrifying doors of high school are opening wide! The firstborns Marco and Eva are far away: he studies music in Milan while she is in New York to specialize in journalism and live with her chef boyfriend, Alex. Their friend Walter, son of Stefania and Enzo, is left hanging around Garbatella, drooling over Carlotta, his beautiful girlfriend from the upper neighborhoods. While walking with Rudi, his passion for mechanics leads him to notice a splendid vintage motorcycle that he inadvertently knocks over.